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Literature summary for 3.4.24.23 extracted from

  • Nukuda, A.; Sasaki, C.; Ishihara, S.; Mizutani, T.; Nakamura, K.; Ayabe, T.; Kawabata, K.; Haga, H.
    Stiff substrates increase YAP-signaling-mediated matrix metalloproteinase-7 expression (2015), Oncogenesis, 4, e165 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene MMP7, enzyme expression analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ metalloproteinase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell YAP is a critical regulatory factor in upregulating MMP-7 expression on the stiffer substrate in colorectal cancer Homo sapiens
-
T-84 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-7
-
 Homo sapiens
MMP-7
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens yes-associated protein (YAP) knockdown decreases MMP-7 expression. Treatment with inhibitors of epidermal growth factor receptor (EGFR) and myosin regulatory light chain (MRLC) and integrin-alpha2 or integrin-beta1 knockdown downregulate MMP-7 expression down
Homo sapiens YAP, EGFR, integrin-alpha2beta1 and MRLC produce a positive feedback loop that enhances MMP-7 expression. Stiff substrates enhance colorectal cancer cell viability by upregulating MMP-7 expression through a positive feedback loop up

General Information

General Information Comment Organism
metabolism yes-associated protein (YAP), EGFR, integrin-alpha2beta1 and MRLC produce a positive feedback loop that enhances MMP-7 expression. Stiff substrates enhance colorectal cancer cell viability by upregulating MMP-7 expression through a positive feedback loop Homo sapiens
physiological function stiff substrates (like plastic) enhance colorectal cancer cell viability by upregulating MMP-7 expression through a positive feedback loop, in contrast to soft substrates (e.g. collagen type I). Yes-associated protein (YAP) activity increases MMP-7 expression on stiffer substrates Homo sapiens