EC Number   |
Expression |
Reference  |
|---|
   3.4.24.17 | down |
interleukin-1Ra, dexamethasone, and TNF significantly decrease levels of all forms of MMP-3 |
707312 |
| 3.4.24.17 | down |
stromelysin-1 is slightly downregulated in obese adipose tissue compared to non-obese adipose tissue. Expression of MMP-3 mRNA in subcutaneous and gonadal adipose tissue is affected and 3.0-3.7fold reduced by MMP-10 deficiency, but vessel size is not affected |
707379 |
| 3.4.24.17 | down |
glycitein, i.e. 4',7-dihydroxy-6-methoxyisoflavone, a bacterial metabolite of the isoflavone glycitin, downregulates MMP-3 gene expression by inhibiting the promoter activity of MMP-3 |
708089 |
| 3.4.24.17 | up |
MMP-3 expression is upregulated with age, overview |
708594 |
| 3.4.24.17 | down |
dexamethasone suppression of MMP-3 gene expression |
709370 |
| 3.4.24.17 | up |
TNF-alpha and interleukin-1beta act synergistically to drive MMP-3 secretion. NF-kappaB and AP-1 c-Jun/FosB heterodimers regulate CoMTb-induced MMP-3 secretion. NF-kappaB p65 and AP-1 c-Jun subunits are upregulated in biopsy granulomas from patients with cerebral tuberculosis. CoMTb upregulates MMP-3 gene expression and secretion in microglia |
709370 |
| 3.4.24.17 | up |
MMP-3 is induced in gingival fibroblasts in response to inflammatory cytokines, such as TNF and interleukin-1 |
709669 |
| 3.4.24.17 | down |
expression of MMP-3 in cartilages and synovial tissues is suppressed by the treatment of curcumin and indomethacin. Production of MMP-3 is inhibited by curcumin in tumor necrosis factor-alpha-stimulated rheumatoid arthritis fibroblast-like synoviocytes and chondrocytes in a dose-dependent manner putatively through the inhibition of PKCdelta and the JNK/c-Jun signaling pathway, overview |
709685 |
| 3.4.24.17 | down |
production of MMP-3 is inhibited by curcumin in collagen-induced arthritis hind paw sections in a dose-dependent manner putatively through the inhibition of PKCdelta and the JNK/c-Jun signaling pathway, overview |
-, 709685 |
| 3.4.24.17 | up |
TNF-alpha and IL-1beta stimulate production of MMPs through the activation of mitogen-activated protein kinases, NF-kappaB and AP-1 |
709685 |
