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EC Number Expression Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B60down treatment of A-549 lung epithelial cells with 17-beta-estradiol reduces the cellular mRNA levels of ACE2 and TMPRSS2 mRNA, while not affecting FURIN expression 764554
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B60up in lung tissues collected from mice that were sub-chronically exposed to air or 0.8 ppm ozone for three weeks, the TMPRSS2 protein and Tmprss2 transcripts are significantly elevated in the extrapulmonary airways, parenchyma, and alveolar macrophages. A significant proportion of additional known SARS-CoV-2 host susceptibility genes are upregulated in alveolar macrophages and parenchyma from ozone-exposed mice 765794
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B60up the expression of ACE2 and TMPRSS2 increases significantly in differentiated cells cultured at air-liquid interface compared with submerged standard culture 765298
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