Literature summary for 3.4.21.B60 extracted from

Guo, W.; Porter, L.M.; Crozier, T.W.; Coates, M.; Jha, A.; McKie, M.; Nathan, J.A.; Lehner, P.J.; Greenwood, E.J.; McCaughan, F.
Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures (2022), Life Sci. Alliance, 5, e202101116 .

Search for more literature for 3.4.21.B60

Application

Application	Comment	Organism
medicine	brief exposure to topical camostat, an orally available serine protease inhibitor, effectively restricts SARS-CoV-2 infection in differentiated primary human airway epithelial cells. Topical TMPRSS2 inhibition when delivered in a clinically relevant and achievable dose to differentiated airways cells markedly restricts SARC-CoV-2 cellular infection. Enzalutamide, an oral androgen receptor antagonist, has no impact on SARS-CoV-2 infection	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
calmostat	topical TMPRSS2 inhibition when delivered in a clinically relevant and achievable dose to differentiated airways cells markedly restricts SARC-CoV-2 cellular infection	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15393	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epithelium	primary human airway epithelial cells at the air-liquid interface	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	the expression of ACE2 and TMPRSS2 increases significantly in differentiated cells cultured at air-liquid interface compared with submerged standard culture	up

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Release 2023.1 (January 2023)