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EC Number Expression Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.8.2.23down the overall transcriptional activity of the main heparan sulfate biosynthesis-involved genes (EXT1, EXT2, NDST1, NDST2, GLCE, HS2ST1, HS3ST1, HS3ST2, HS6ST1, HS6ST2, SULF1, SULF2, HPSE) is decreased by 1.5-2fold in Grade II-III glioma (p < 0.01) and by 3-fold in Grade IV glioma (glioblastoma multiforme, GBM) (p < 0.05), as compared with the para-tumourous tissue 759360
Display the word mapDisplay the reaction diagram Show all sequences 2.8.2.23down ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis. CRISPR-mediated targeting and siRNA knockdown of ZNF263 in mammalian cell lines and human primary cells leads to dramatically increased expression levels of HS3ST1. LC-MS analysis of lyase-resistant 3-O-sulfated tetrasaccharides derived from ZNF263-/- cells 762294
Display the word mapDisplay the reaction diagram Show all sequences 2.8.2.23more expression of the genes encoding HS-modifying enzymes is frequently dysregulated in cancer and other diseases 761164
Display the word mapDisplay the reaction diagram Show all sequences 2.8.2.23up exposure of chondrosarcoma cells to 5-aza-2'-deoxycytidine up-regulates expression of 3-OST1 mRNA 703620
Display the word mapDisplay the reaction diagram Show all sequences 2.8.2.23up increasing TRF2 level leads to an upregulation of HS3ST4 gene expression 761164
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