EC Number   |
Expression |
Reference |
|---|
   2.7.1.105 | down |
in cells with ERN1 loss of function decreases PFKFB2 mRNA |
739621 |
| 2.7.1.105 | down |
p53 downregulates PFKFB4 expression by binding to its promoter and mediating transcriptional repression via histone deacetylases |
751761 |
| 2.7.1.105 | more |
ectopic expression of wild type PFKFB3 increases phosphorylation of the cell cycle inhibitor p27, a member of the Kip/Cip family of proteins and a universal inhibitor of cyclin-dependent kinases and the cell cycle, at threonine 187 and decreases total p27 protein levels |
698929 |
| 2.7.1.105 | more |
ERN1 loss of function and hypoxic conditions do not affect PFKFB1 mRNA levels |
739621 |
| 2.7.1.105 | more |
hypoxic conditions do not affect PFKFB2 mRNA levels |
739621 |
| 2.7.1.105 | up |
bifunctional 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 mRNA expression is greater in metastatic prostate cancer compared with primary tumors |
721964 |
| 2.7.1.105 | up |
blocking the function of ERN1 enzyme, the key endoplasmic reticulum stress sensor, leads to an increase in the expression levels of PFKFB1, PFKFB2, PFKFB3 and PFKFB4 mRNA, being more significant for PFKFB4 and PFKFB2 |
739621 |
| 2.7.1.105 | up |
blocking the function of ERN1 enzyme, the key endoplasmic reticulum stress sensor, leads to an increase in the expression levels of PFKFB1, PFKFB2, PFKFB3 and PFKFB4 mRNA, being more significant for PFKFB4 and PFKFB2. Hypoxic conditions leads to an increase of the expression level of PFKFB3 and PFKFB4 mRNA both in control glioma cells and cells with ERN1 loss of function, being more significant for PFKFB4. The blockade of ERN1 signaling enzyme function decreases the effect of hypoxia on the expression level of both PFKFB3 and PFKFB4 mRN |
739621 |
| 2.7.1.105 | up |
enzyme expression in esophageal squamous cell carcinoma cell is significantly higher than in adjacent non-tumor tissues |
761806 |
| 2.7.1.105 | up |
isozyme PFKFB3 variant I-PFK2 is inducible |
737973 |
