EC Number   |
Expression |
Reference |
|---|
    2.7.1.1 | down |
a small heterodimer partner decreasesliver glucokinase gene expression by inhibiting the transcriptional activity of liver X receptoralpha and peroxisome proliferator-activated receptor-gamma by directly interacting with their common heterodimer partner RXRalpha |
704479 |
| 2.7.1.1 | down |
the glucokinase protein levels in liver of alloxan treated mice is only 19% of that of normal mice |
702535 |
| 2.7.1.1 | down |
treatment with gibberellin GA3 results in the inhibition of Hxk1 and Hxk2 expression levels with the increase of GA3 concentrations. In presence of 20 mM glucosamine, expression is almost completely suppressed |
-, 739038 |
| 2.7.1.1 | down |
when oroxylin A, isolated from Scutellaria baicalensis and Oroxylum indicum, is applied to two breast carcinoma cell lines, it decreases hexokinase II expression and causes detachment of the enzyme from the mitochondria, thereby inhibiting glycolysis and decreasing ATP levels |
758656 |
| 2.7.1.1 | up |
biotin increases glucokinase expression, inhibition of soluble guanylate cyclase or protein kinase G signalling suppresses biotin-induced glucokinase expression, inhibition of insulin secretion with diazoxide or nifedipine prevents biotin-stimulated glucokinase mRNA increase |
705294 |
| 2.7.1.1 | up |
expression is upregulated in three-leaf stage shoots treated with exogenous abscisic acid, cytokinin, gibberellic acid, auxin, polyehtylene glycol, sodium chloride, and low temperature of 4°C |
739036 |
| 2.7.1.1 | up |
higher levels in heterotrophic tissues, developing seeds and roots, than in photosynthetic ones. A time course of HXK activity and expression in seeds shows that the highest HXK levels are found at the early stages of reserve compounds, lipids and proteins accumulation |
723049 |
| 2.7.1.1 | up |
Hxk1 and Hxk2 expression levels rise with increasing glucose concentrations |
-, 739038 |
| 2.7.1.1 | up |
in contrast to normal brain and low-grade gliomas, which express predominantly HK1, human glioblastoma multiforme show show increased HK2 expression |
722876 |
| 2.7.1.1 | up |
in the liver, expression of glucokinase is strictly dependent on the presence of insulin, insulin induction of glucokinase in hepatocytes is suppressed by the inhibitors of phosphoinositide 3-kinase, wortmannin, and LY294002 |
703129 |
