EC Number   |
Expression |
Reference |
|---|
    1.17.4.1 | down |
the thiazolyl hydrazone VG19 lowers the protein levels of ribonucleotide reductase subunits R1 and R2 and significantly diminishes the incorporation of radio-labeled 14C cytidine, being equivalent to an inhibition of DNA synthesis |
744958 |
| 1.17.4.1 | down |
the thiazolyl hydrazone VG19 lowers the protein levels of ribonucleotide reductase subunits R1 and R2 and significantly diminishes the incorporation of radio-labeled 14Ccytidine, being equivalent to an inhibition of DNA synthesis |
744958 |
| 1.17.4.1 | more |
ribonucleotide reductase subunit mRNA levels are comparably low in both damaged and undamaged G1 cells and highly induced in damaged S/G2 cells. Transcript numbers becomes correlated with both protein levels and localization only upon DNA damage in a cell cycle-dependent manner. The differential ribonucleotide reductase response to DNA damage correlates with variable Mec1 kinase activity in the cell cycle in single cells. The transcription of ribonucleotide reductase genes is noisy and non-Poissonian in nature |
728298 |
| 1.17.4.1 | up |
class Ib RNR is expressed under iron-limited and oxidative stress conditions |
714184 |
| 1.17.4.1 | up |
isoform NrdEF is induced during H2O2 stress. Induction is mediated by the inactivation of Fur, an iron-dependent repressor. NrdEF supports cell replication in iron-depleted cells. Iron binds to NrdF when it is expressed in iron-rich cells, but NrdEF is functional only in cells that are both iron-depleted and manganese-rich |
728322 |
| 1.17.4.1 | up |
ribonucleotide reductase overexpression leads to a shortened chromosome replication (C period) compared with that of a wild-type strain |
745680 |
| 1.17.4.1 | up |
RNR genes are induced in cells grown in Luria-Bertani medium, with levels of NrdE and NrdF elevated 35fold relative to that of the wild-type strain |
-, 714258 |
| 1.17.4.1 | up |
subunit RRM2B is induced in response to hypoxia |
745759 |
