EC Number |
BRENDA No. |
Title |
Journal |
Volume |
Pages |
Year |
Organism |
PubMed ID |
---|
3.4.21.47 | 754745 |
The human complement receptor type 2 (CR2)/CR1 fusion protein TT32, a novel targeted inhibitor of the classical and alternative pathway C3 convertases, prevents arthritis in active immunization and passive transfer mouse models |
Mol. Immunol. |
105 |
150-164 |
2019 |
Homo sapiens |
30513451 |
3.4.21.47 | 753082 |
Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes |
BMC Biol. |
13 |
93 |
2015 |
Homo sapiens |
26552476 |
3.4.21.47 | 755170 |
Neisseria heparin binding antigen is targeted by the human alternative pathway C3-convertase |
PLoS ONE |
13 |
e0194662 |
2018 |
Homo sapiens |
29579105 |
3.4.21.47 | 753422 |
Bacterial killing by complement requires membrane attack complex formation via surface-bound C5 convertases |
EMBO J. |
38 |
e99852 |
2019 |
Homo sapiens |
30643019 |
3.4.21.47 | 752433 |
C5 convertase blockade in membranoproliferative glomerulonephritis a single-arm clinical trial |
Am. J. Kidney Dis. |
74 |
224-238 |
2019 |
Homo sapiens |
30929851 |
3.4.21.47 | 753663 |
Functional characterization of alternative and classical pathway C3/C5 convertase activity and inhibition using purified models |
Front. Immunol. |
9 |
1691 |
2018 |
Homo sapiens |
30083158 |
3.4.21.47 | 710039 |
Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor |
Nat. Immunol. |
10 |
721-727 |
2009 |
Homo sapiens |
19503103 |
3.4.21.47 | 710040 |
Structure of complement fragment C3b-factor H and implications for host protection by complement regulators |
Nat. Immunol. |
10 |
728-733 |
2009 |
Homo sapiens |
19503104 |
3.4.21.47 | 701017 |
3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase |
Proc. Natl. Acad. Sci. USA |
106 |
882-887 |
2009 |
Homo sapiens |
19136636 |
3.4.21.47 | 710434 |
Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus |
Proc. Natl. Acad. Sci. USA |
107 |
3681-3686 |
2010 |
Homo sapiens |
20133685 |