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EC Number BRENDA No. Title Journal Volume Pages Year Organism PubMed ID
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.84678447 Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones Biochim. Biophys. Acta 1773 853-862 2007 Homo sapiens 17467817
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.84682549 HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells Proc. Natl. Acad. Sci. USA 104 13432-13437 2007 Mus musculus 17652517
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.84712629 Accelerated features of age-related bone loss in zmpste24 metalloproteinase-deficient mice J. Gerontol. A Biol. Sci. Med. Sci. 64 1015-1024 2009 Mus musculus 19587107
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.84718809 HIV protease inhibitors inhibit FACE1/ZMPSTE24: a mechanism for acquired lipodystrophy in patients on highly active antiretroviral therapy? Biochem. Soc. Trans. 38 292-296 2010 Homo sapiens 20074077
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.84710803 Novel frameshifting mutations of the ZMPSTE24 gene in two siblings affected with restrictive dermopathy and review of the mutations described in the literature Am. J. Med. Genet. A 152A 447-452 2010 Homo sapiens 20101687
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.84719313 Homozygous null mutations in ZMPSTE24 in restrictive dermopathy: evidence of genetic heterogeneity Clin. Genet. 81 158-164 2012 Homo sapiens 21108632
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.84735044 Requirements for efficient proteolytic cleavage of prelamin A by ZMPSTE24 PLoS ONE 7 e32120 2012 Homo sapiens 22355414
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.84754136 Ste24p mediates proteolysis of both isoprenylated and non-prenylated oligopeptides J. Biol. Chem. 291 14185-14198 2016 Saccharomyces mikatae 27129777
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.84755334 Human CaaX protease ZMPSTE24 expressed in yeast Structure and inhibition by HIV protease inhibitors Protein Sci. 26 242-257 2017 Homo sapiens 27774687
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.84753395 ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability Dis. Model. Mech. 11 dmm033670 2018 Homo sapiens 29794150
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