EC Number |
Reaction |
Reference |
---|
1.14.16.2 | L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine |
active binding site |
438700 |
1.14.16.2 | L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine |
H-NMR analysis of conformation of the complex between phenylalanine, 6-methyltetrahydropterin and isoform hTH1 |
438703 |
1.14.16.2 | L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine |
ligand binding model, hTH1 |
438710 |
1.14.16.2 | L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine |
mechanism |
438686, 438701, 438711 |
1.14.16.2 | L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine |
phosphorylation site of hTH1 is Ser-40 |
438708 |
1.14.16.2 | L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine |
requires Fe2+, activated by phosphorylation, catalysed by EC 2.7.1.128 [acetyl-CoA carboxylase] kinase |
- |
1.14.16.2 | L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine |
secondary structure and conformation analysis of phosphorylated and unphosphorylated isoform hTH1 |
438708 |
1.14.16.2 | L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine |
stereochemical analysis of ligand binding |
438700 |