EC Number   |
Posttranslational Modification |
Reference |
|---|
   3.2.2.29 | acetylation |
TDG lysines are acetylated by CREB-binding protein, CBP, and p300. Acetylation of the N-terminal region abrogates high-affinity DNA binding and selectively prevents processing of G:T mispairs. TDG acetylation and phosphorylation are mutually exclusive, and their interplay dramatically alters the DNA mispair-processing functions of TDG |
710145 |
| 3.2.2.29 | more |
TDG catalytic efficiency of the protein is increased by SUMOylation |
710229 |
| 3.2.2.29 | phosphoprotein |
protein kinase C alpha interacts with TDG and phosphorylates N-terminal serine residues adjacent to lysines acetylated by CREB-binding protein, CBP, and p300. TDG acetylation and phosphorylation are mutually exclusive, and their interplay dramatically alters the DNA mispair-processing functions of TDG. Phosphorylation does not markedly alter DNA interactions, but may preserve G:T processing in vivo by preventing CBP-mediated acetylation |
710145 |
