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Literature summary for 3.2.2.29 extracted from

  • Mohan, R.D.; Litchfield, D.W.; Torchia, J.; Tini, M.
    Opposing regulatory roles of phosphorylation and acetylation in DNA mispair processing by thymine DNA glycosylase (2010), Nucleic Acids Res., 38, 1135-1148.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in NIH3T3 fibroblasts Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Mus musculus 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
cellular TDG demonstrates PMA-dependent alterations in apparent molecular weight and isoelectric point Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus TDG performs DNA processing of G:T mispairs ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
acetylation TDG lysines are acetylated by CREB-binding protein, CBP, and p300. Acetylation of the N-terminal region abrogates high-affinity DNA binding and selectively prevents processing of G:T mispairs. TDG acetylation and phosphorylation are mutually exclusive, and their interplay dramatically alters the DNA mispair-processing functions of TDG Mus musculus
phosphoprotein protein kinase C alpha interacts with TDG and phosphorylates N-terminal serine residues adjacent to lysines acetylated by CREB-binding protein, CBP, and p300. TDG acetylation and phosphorylation are mutually exclusive, and their interplay dramatically alters the DNA mispair-processing functions of TDG. Phosphorylation does not markedly alter DNA interactions, but may preserve G:T processing in vivo by preventing CBP-mediated acetylation Mus musculus

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme from NIH3T3 fibroblasts Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
NIH-3T3 cell
-
Mus musculus
-
P-19 cell EC cell Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information TDG performs DNA processing of G:T mispairs Mus musculus ?
-
?
additional information TDG performs DNA processing of G:T mispairs, base excision from oligonucleotides containing a single G:U or G:T mispair Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
TDG
-
Mus musculus
thymine DNA glycosylase
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
assay at Mus musculus

pI Value

Organism Comment pI Value Maximum pI Value
Mus musculus cellular TDG demonstrates PMA-dependent alterations in apparent molecular weight and isoelectric point
-
additional information

General Information

General Information Comment Organism
additional information opposing roles of CBP/p300 and PKCalpha in regulating the DNA repair functions of TDG, the interplay of acetylation and phosphorylation of TDG in vivo may be critically important in the maintenance of CpG dinucleotides and epigenetic regulation Mus musculus
physiological function TDG plays an integral role in CpG maintenance by excising mispaired thymine and uracil in a CpG context and also participates in transcriptional regulation via gene-specific CpG demethylation and functional interactions with the transcription machinery Mus musculus