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Posttranslational Modification
Commentary
Reference
1.3.1.72
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DHCR24 is also regulated post-translationally, overview
746354
1.3.1.72
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enzyme possesses a potential N-terminal secretory signal
654165
1.3.1.72
phosphoprotein
protein kinase C (PKC) activates DHCR24 activity through reversible phosphorylation. PKC inhibitors, BIM and Ro-318220, reduce cholesterol levels and accumulate desmosterol within 4 h, indicating decreased DHCR24 activity. Phosphorylation at T110 modulates DHCR24 activity
745512
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