EC Number   |
Application |
Reference |
|---|
    6.1.1.2 | biotechnology |
EcTrpRS is used as a model system for in silicio docking studies with various Trp analogs using the FlexX-Pharm strategy. Relative binding energies for Trp analogs in TrpRS are calculated that correlate well with their translational activities in Escherichia coli. FlexX-Pharm predicted the binding sites of fluoro-, amino-, hydroxyl- and aza-containing Trp analogs within 1.5 A of Trp in the homology model of EcTrpRS |
691148 |
| 6.1.1.2 | medicine |
as producers of nearly half of the 10000 known antibiotics, Streptomyces bacteria have been particularly important in drug discovery and are a major source of drug resistance genes |
701740 |
| 6.1.1.2 | medicine |
enzyme is the target for antibacterial activity of chuangximycin and chuangximycin lactone |
650562 |
| 6.1.1.2 | medicine |
human mini, but not full-length, TrpRS has angiostatic activity |
702375 |
| 6.1.1.2 | medicine |
TrpRS is differentially expressed in colorectal cancer and thus a potential prognostic marker |
703001 |
| 6.1.1.2 | synthesis |
a functional, orthogonal suppressor tRNA pair can prove useful for the incorporation of bulky, unnatural amino acids into the genetic code. Role of tRNA flexibility in molecular recognition and the engineering and evolution of tRNA specificity |
-, 716373 |
