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EC Number Application Commentary Reference
Display the reaction diagram Show all sequences 4.2.3.42synthesis synthesis of aphidicolin, inhibitor of DNA polymerase alpha, by heterologous expression of the genes encoding geranlygeranyl diphosphate synthase, aphidicolan-16beta-ol synthase, and monooxygenases P450-1 and P450-1 from Phoma betae in Aspergillus oryzae. Host Saccharomyces cerevisiae, carrying the genes encoding geranlygeranyl diphosphate synthase and aphidicolan-16beta-ol, produces aphidicolan-16beta-ol 714535
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