EC Number |
Application |
Reference |
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3.2.1.51 | diagnostics |
alpha-L-fucosidase is a valuable diagnostic biomarker for hepatocellular carcinoma. An ultrasensitive plasmonic biosensor converts plasmonic absorption to electrical current in order to detect alpha-L-fucosidase and cardiac troponin I using whole human blood in a real-time and parallel fashion. The detection limit is calculated to be 0.016 U/L for alpha-L-fucosidase and 0.015 ng/mL for cardiac troponin I, respectively. The developed biosensor exhibits a promising application for the prediction of cancers and many other diseases |
749568 |
3.2.1.51 | diagnostics |
combined detection of the three tumor markers, serum alpha-L-fucosidase, alpha-fetoprotein and thymidine kinase 1 can play a complementary role in the diagnosis of hepatocellular carcinoma, and can significantly improve the sensitivity for the diagnosis of hepatocellular carcinoma |
750551 |
3.2.1.51 | analysis |
comparison of glycolytic and chitinolytic enzyme activities between desert and oasis flies of Phlebotomus papatasi to evaluate potential differences in susceptibility to infection with Leishmania major |
679943 |
3.2.1.51 | medicine |
deficiency in enzyme activity is associated with fucosidosis |
656203 |
3.2.1.51 | medicine |
gastric cancer cells infected with Helicobacter pylori secrete isoform Fuc2A. Fuc2A is essential for Helicobacter pylori adhesion, in particular to the gastric cancer- and duodenal ulcer-specific strains. FUCA2 significantly enhances the expression of Lewis x antigen in Helicobacter pylori, which is critical for bacterial cell adhesion in the pathogenesis and defense strategy to escape host surveillance |
710413 |
3.2.1.51 | medicine |
has a role in the intimate species signature interactions between sperm and oocyte. Relevance for reproductive function in nature or in assisted reproductive technologies |
682040 |
3.2.1.51 | analysis |
low cost and accurate method for the detection and analytical determination of the activity of enzyme alpha-L-fucosidase. The method is based upon measuring the fluorescence intensity of the complex ion associate of the ion associate of rhodamine-B and the compound 2-chloro-4-nitrophenol at 580 nm in phosphate buffer, pH 5 against the reagent blank. The correlation between the fluorescence activity of the enzyme by the developed procedures and the standard method is positive and highly significant in patients and controls. The developed method is simple and proceeds without practical artifacts compared to the standard method |
710595 |
3.2.1.51 | medicine |
may be useful as a biomarker for predicting the progression-free survival of for trastuzumab treatment |
699825 |
3.2.1.51 | medicine |
progression-free survival significantly longer in high FUCA activity group than in low FUCA activity group, not correlated to clinical response to trastuzumab but maybe useful as biomarker for predicting progression-free survival for trastuzumab treatment, serum FUCA activity correlates with early detection in hepatocellular carcinoma |
699825 |
3.2.1.51 | medicine |
quality of semen is affected in part by the loss in the activity of alpha-fucosidase, which may be useful in early diagnosis of the loss in reproductive capacity during the course of trypanosomiasis and fertility tests |
680897 |