EC Number   |
Application |
Reference |
|---|
   3.1.4.39 | analysis |
fluorogenic substrates, potential in screening for inhibitors and for monitoring spatiotemporal changes in activity in cells |
682231 |
| 3.1.4.39 | analysis |
the purified ATX protein is enzymatically active and biologically functional, offering a useful tool for further biological and structural studies of this important enzyme |
714603 |
| 3.1.4.39 | diagnostics |
lysoPLD assay can be applied to clinical laboratory testing. Serum lysoPLD activity in healthy female subjects is significantly higher than that in male subjects. It seems likely that lysoPLD and its product lysophosphatidic acid participate in female reproductive biology. lysoPLD assay method seems to be promising for laboratory testing because it allows easy handling of the samples |
679257 |
| 3.1.4.39 | drug development |
ATX is a target for cancer treatment |
714038 |
| 3.1.4.39 | drug development |
ATX is one of the target molecules for cancer therapy, therefore the immuno-neutralization by an antibody which is able to recognize the catalytic site, or the low molecular weight chemical inhibitors based on structural biology should be a useful tool for prevention or treatment of tumor progression and metastasis |
682694 |
| 3.1.4.39 | drug development |
the enzyme is a good target for small molecule inhibitors |
730155 |
| 3.1.4.39 | drug development |
to inhibit lysophosphatidic acid production in the blood. Inhibition of autotaxin/lysoPLD activity by small molecules could be an effective new therapeutic approach for cancer and possibly cardiovascular disease |
681769 |
| 3.1.4.39 | medicine |
autotaxin gene expression is significantly higher in neoplastic endometrium compared with normal tissue. The expression of autotaxin is significantly elevated in type I endometrial cancer compared to type II, in premenopausal women and in patients affected either by obesity or diabetes |
751460 |
| 3.1.4.39 | medicine |
autotaxin is an attractive target for the anticancer therapeutics that inhibit angiogenesis, invasion, and migration |
714443 |
| 3.1.4.39 | medicine |
inhibitors of autotaxin can be used as a therapy for the treatment of cancer |
704477 |
