Any feedback?
Literature summary for 3.1.4.39 extracted from
- Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin (2011), Bioorg. Med. Chem. Lett., 21, 5098-5101.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | autotaxin is an attractive target for the anticancer therapeutics that inhibit angiogenesis, invasion, and migration | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cyclohexanaminium hydrogen [4-(decanoylamino)benzyl]phosphonate | - |
Homo sapiens |  |
| cyclohexanaminium hydrogen [4-(heptanoylamino)benzyl]phosphonate | - |
Homo sapiens | |
| cyclohexanaminium hydrogen [4-(tetradecanoylamino)benzyl]phosphonate | - |
Homo sapiens | |
| cyclohexanaminium hydrogen [4-([3-[2-(2-methoxyethoxy)ethoxy]propanoyl]amino)benzyl]phosphonate | - |
Homo sapiens | |
| cyclohexanaminium hydrogen [fluoro[4-(heptanoylamino)phenyl]methyl]phosphonate | - |
Homo sapiens | |
| cyclohexanaminium hydrogen [[4-(decanoylamino)phenyl](fluoro)methyl]phosphonate | - |
Homo sapiens | |
| cyclohexanaminium hydrogen [[4-(decanoylamino)phenyl](hydroxy)methyl]phosphonate | - |
Homo sapiens | |
| cyclohexanaminium hydrogen [[4-(heptanoylamino)phenyl](hydroxy)methyl]phosphonate | - |
Homo sapiens | |
| additional information | no inhibition by 4 at 0.01 mM | Homo sapiens | |
| S32826 | - |
Homo sapiens | |
| [4-(tetradecanoylamino)benzyl]phosphonic acid | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | the enzyme is secreted | Homo sapiens | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ATX | - |
Homo sapiens |
| autotaxin | - |
Homo sapiens |
| lysophospholipase D | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000061 | - |
cyclohexanaminium hydrogen [[4-(decanoylamino)phenyl](fluoro)methyl]phosphonate | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000009 | - |
cyclohexanaminium hydrogen [4-(tetradecanoylamino)benzyl]phosphonate | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000018 | - |
cyclohexanaminium hydrogen [4-(decanoylamino)benzyl]phosphonate | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000024 | - |
cyclohexanaminium hydrogen [[4-(decanoylamino)phenyl](hydroxy)methyl]phosphonate | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0000242 | - |
cyclohexanaminium hydrogen [[4-(decanoylamino)phenyl](hydroxy)methyl]phosphonate | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000072 | - |
cyclohexanaminium hydrogen [[4-(decanoylamino)phenyl](fluoro)methyl]phosphonate | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000512 | - |
cyclohexanaminium hydrogen [4-(heptanoylamino)benzyl]phosphonate | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000834 | - |
cyclohexanaminium hydrogen [fluoro[4-(heptanoylamino)phenyl]methyl]phosphonate | pH and temperature not specified in the publication | Homo sapiens | |
| 0.001009 | - |
cyclohexanaminium hydrogen [[4-(heptanoylamino)phenyl](hydroxy)methyl]phosphonate | pH and temperature not specified in the publication | Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | lysophospholipase D hydrolyzes lysophosphatidylcholine to form the bioactive lipid lysophosphatidic acid | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
