EC Number   |
Application |
Reference |
|---|
    1.11.1.9 | analysis |
activity is important in predicting tissue redox state |
677215 |
| 1.11.1.9 | analysis |
method of measuring of glutathione peroxidase activity using H2O2. At a concentration of reduced glutathione of 0.55 mM, the concentration of H2O2 of 0.192 mM is saturating for glutathione peroxidase. The duration of incubation does not exceed 60 sec, if 13% homogenate is used |
764392 |
| 1.11.1.9 | medicine |
for patients with sepsis, geometric mean Gpx3 bioactivity is 78.13 U/l , significantly lower than for normal subjects with 108.21 U/l. The GPx3 protein concentration is significantly lower in patients with sepsis than in normal subjects, with the mean Gpx3 value of 0.78 vs 3.10 microg/ml, respectively. A positive correlation is observed between the Gpx3 bioactivity and its corresponding protein concentration in septic serum samples, regardless of gender or age difference |
764515 |
| 1.11.1.9 | medicine |
in liver, by 24 h, exposure to alow dose of Cd causes 13% loss of Gpx4a expression. At higher dose, Cd leads to 40% decrease in Gpx4a expression. Longer exposure periods cause about 20% loss of liver Gpx4a expression by low Cd dose |
724102 |
| 1.11.1.9 | medicine |
olfactory isoform Gpx4b mRNA expression is not extensively modulated by presence of cadmium ions. In liver, by 24 h, exposure to alow dose of Cd causes 18% loss of Gpx4b expression. At higher dose, Cd leads to 37% decrease in Gpx4b expression. Longer exposure periods cause about 22% loss of liver Gpx4b expression by low Cd dose, whereas at higher Cd exposures, a 33% loss in Gpx4b expression is observed |
724102 |
| 1.11.1.9 | medicine |
the activities of superoxide dismutase and glutathione peroxidase in a population chronically exposed to high levels of radon indoors does not differ from those in the control group (0.37 versus 0.28 U/mg protein and 8.46 versus 8.34 U/mg protein). For both populations, there is a significant positive correlation between superoxide dismutase and glutathione peroxidase activities. No significant effects of gender, age, smoking habit, and body mass index on superoxide dismutase and glutathione peroxidase activities are found for both groups |
764714 |
| 1.11.1.9 | medicine |
the enzyme has potential therapeutic value as an antioxidant, but its pharmacological development is limited because the enzyme uses a selenocysteine as its catalytic group and it is difficult to generate selenium-containing proteins with traditional recombinant DNA technology |
658429 |
| 1.11.1.9 | synthesis |
construction of a smart artificial glutathione peroxidase triggered by directed self-assembly of supraamphiphiles composed of cyclodextrin-based telluronic acid. The nanostructures conveniently link the catalytic center of glutathione peroxidase and thermosensitive polymer to the host cyclodextrin molecules.By changing the temperature, the peroxidase activity can be switched on and off |
743190 |
| 1.11.1.9 | synthesis |
construction of recombinant proteins carrying both the activity of human glutathione peroxidase and Alvinella pompejana superoxide dismutase and expression in a single protein production system. The best construct displays excellent antioxidant capacity and synergistic effects of hte two activities |
742554 |
| 1.11.1.9 | synthesis |
preparation of a supramolecular artificial glutathione peroxidase based on a supramolecular graft copolymer and the catalytic center ADA-Te-OH. The artificial glutathione peroxidase was constructed by supramolecular host-guest self-assembly and displays noticeable temperature-dependent catalytic activity and typical saturation kinetics behavior. The change in the self-assembled structure during the temperature-dependent process plays a significant role in the temperature-dependent catalytic behavior |
742280 |
