EC Number   |
Natural Substrates |
|---|
    6.3.1.9 | gamma-L-glutamyl-L-cysteinyl-glycine + N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ATP |
- |
| 6.3.1.9 | glutathione + glutathionylspermidine + ATP |
- |
| 6.3.1.9 | glutathione + spermidine + 2 ATP |
- |
| 6.3.1.9 | glutathione + spermidine + ATP |
- |
| 6.3.1.9 | 2 glutathione + spermidine + 2 ATP |
important reaction in defense against chemical and oxidant stress, thiol redox homeostasis, ribonucleotide metabolism, and drug resistance in parasitic kinetoplastids |
| 6.3.1.9 | more |
in pathogenic trypanosomes, trypanothione synthetase catalyzes the synthesis of both glutathionylspermidine and trypanothione (bis(glutathionyl)spermidine). Trypanothione is synthesized from two molecules of GSH that are covalently bridged by a spermidine in two ATP-dependent reactions. The enzyme also shows trypanothione amidase activity catalyzed at a second distinct active site |
| 6.3.1.9 | 2 glutathione + spermidine + 2 ATP |
overall reaction, the enzyme catalyzes the formation of N1,N8-bis(glutathionyl)spermidine in two reaction steps, exhibiting activity of EC 6.3.1.8, glutathionylspermidine synthase, and 6.3.1.9, trypanothione synthase |
| 6.3.1.9 | 2 glutathione + spermidine + 2 ATP |
overall reaction, the enzyme catalyzes the formation of N1,N8-bis(glutathionyl)spermidine in two reaction steps, exhibiting activity of EC 6.3.1.8, glutathionylspermidine synthase, and 6.3.1.9, trypanothione synthase, overview |
| 6.3.1.9 | more |
phylogenetic analysis implies that TryS will replace the glutathionylspermidine synthase/trypanothione synthase complex in Leishmia major loosing the redundant GspS pseudogene from its genome |
| 6.3.1.9 | glutathione + spermidine + ATP |
reaction of EC 6.3.1.8, step one |
