EC Number   |
Natural Substrates |
|---|
    3.6.1.23 | dCTP + H2O |
- |
| 3.6.1.23 | dUTP + H2O |
- |
| 3.6.1.23 | dUTP + H2O |
a preventive DNA repair enzyme, contributes to maintain the appropriate cellular dUTP/dTTP ratio by catalyzing dUTP hydrolysis, dUTPase is essential for viability |
| 3.6.1.23 | dUTP + H2O |
an efficient preventive repair pathway, avoiding uracil in DNA, is generally present that keeps cellular dUTP/dTTP levels at a much decreased value to prevent use of dUTP as a building block by DNA polymerases. The enzyme responsible for this sanitizing role is dUTPase, a ubiquitous protein |
| 3.6.1.23 | more |
biological functions in housekeeping, overview |
| 3.6.1.23 | dUTP + H2O |
biological roles and functions of dUTPase-related proteins and domains, overview |
| 3.6.1.23 | dUTP + H2O |
dUMP is required for biosynthesis of dTTP, overview |
| 3.6.1.23 | dUTP + H2O |
dUTP is constantly produced in the pyrimidine biosynthesis network. To prevent uracil incorporation into DNA, representatives of the dUTP nucleotidohydrolase enzyme family eliminate excess dUTP as one moethod to avoid uracil nucleotides incorporation into DNA, besides exchanging dUTP for dTTP as a second method, overview |
| 3.6.1.23 | dUTP + H2O |
dUTPase catalyzes the hydrolysis of dUTP to dUMP and diphosphate controlling the incorporation of uracil into DNA genomes |
| 3.6.1.23 | dUTP + H2O |
dUTPase has a dual role in pyrimidine nucleotide metabolism, it provides the substrate for the thymidylate synthase allowing the formation of dTTP. Secondly, the enzyme is responsible for keeping dUTP intracellular levels low, avoiding its misincorporation into nascent DNA |
