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Information on EC 3.6.1.23 - dUTP diphosphatase

for references in articles please use BRENDA:EC3.6.1.23

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IUBMB Comments

The enzyme catalyses the Mg2+-dependent hydrolysis of dUTP to dUMP, providing the substrate for EC 2.1.1.45, thymidylate synthase, leading to production of thymidine nucleotides. By reducing the effective ratio of dUTP to TTP, the enzyme also reduces the possibility of dUTP incorporation into DNA.

The enzyme appears in viruses and cellular organisms
Reaction Schemes

Synonyms
dutpase, deoxyuridine triphosphatase, deoxyuridine triphosphate nucleotidohydrolase, deoxyuridine 5'-triphosphate nucleotidohydrolase, dut-n, deoxyuridine 5'-triphosphate, dutp pyrophosphatase, dutp nucleotidohydrolase, orf 54, dcd-dut, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dUTP + H2O = dUMP + diphosphate
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
pyrimidine deoxyribonucleotides de novo biosynthesis I, pyrimidine deoxyribonucleotides de novo biosynthesis II, pyrimidine deoxyribonucleotides de novo biosynthesis III, pyrimidine deoxyribonucleotides dephosphorylation, superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)