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EC Number	Natural Substrates	Commentary (Nat. Sub.)
3.5.4.35	cytosine8 in tRNA + H2O	all canonical tRNAs have a uridine at position 8, involved in maintaining tRNA tertiary structure. The hyperthermophilic archaeon Methanopyrus kandleri harbors 30 (out of 34) tRNA genes with cytidine at position 8. The enzyme catalyzes C-to-U editing at this location. The presence of this C-to-U editing enzyme guarantees the proper folding and functionality of all Methanopyrus kandleri tRNAs

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Release 2023.1 (January 2023)