EC Number   |
Natural Substrates |
|---|
   3.4.22.1 | amyloid-beta + H2O |
- |
| 3.4.22.1 | caspase 1 precursor + H2O |
- |
| 3.4.22.1 | Collagen + H2O |
- |
| 3.4.22.1 | Collagen IV + H2O |
- |
| 3.4.22.1 | Gelatin + H2O |
- |
| 3.4.22.1 | ovalbumin + H2O |
- |
| 3.4.22.1 | Proteins + H2O |
- |
| 3.4.22.1 | more |
absence of Ctsb significantly impairs development of high-grade invasive ductal carcinomas and reduces the metastatic burden in the lungs, and cancer cells lacking Ctsb exhibit significantly higher resistance to apoptosis induction by the lysosomotropic agent Leu-Leu-OMe |
| 3.4.22.1 | Phe-Lys-4-aminobenzyloxycarbonyl-doxorubicin prodrug-albumin + H2O |
albumin-binding prodrug of doxorubicin, which incorporates a maleimide moiety and a 4-aminobenzyloxycarbonyl spacer coupled to the dipeptide Phe-Lys, is cleaved by cathepsin B and in tumor homogenates of MDA-MB 435 tumor cells from in vitro culture transplanted subcutaneously into the left flank region of mice, overview |
| 3.4.22.1 | more |
autocatalytic activation of procathepsin B is largely insensitive to mutations in the cleavage site region and can proceed at neutral pH when bound to heparin and other negatively charged surfaces, which may account for an extracellular physiological role of cathepsins |
