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Results 1 - 4 of 4

EC Number	Natural Substrates	Commentary (Nat. Sub.)
2.7.1.164	ATP + L-seryl-tRNASec	-
2.7.1.164	ATP + L-seryl-tRNASec	null mutants of PSTK abolish selenoprotein synthesis, demonstrating the essentiality of the enzyme for the formation of L-selenocysteinyl-tRNASec. Growth of the knockout strain is not impaired. Thus, unlike mammals, trypanosomes do not require selenoproteins for viability
2.7.1.164	ATP + L-seryl-tRNASec	Pstk is a limiting factor for hepatic selenoprotein biosynthesis, and its mRNA expression is most strongly affected during the lipopolysaccharide (LPS)-induced acute-phase response
2.7.1.164	ATP + seryl-tRNASec	L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS)

Results 1 - 4 of 4

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Release 2023.1 (January 2023)