EC Number   |
Natural Substrates |
|---|
   2.4.1.109 | dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] |
- |
| 2.4.1.109 | dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] |
- |
| 2.4.1.109 | dolichyl phosphate D-mannose + protein |
- |
| 2.4.1.109 | dolichyl phosphate D-mannose + protein |
acceptor substrate specificities of PMT1-4,6 |
| 2.4.1.109 | dolichyl phosphate D-mannose + protein |
acceptor substrates: secretory proteins |
| 2.4.1.109 | dolichyl phosphate D-mannose + protein Aga2 |
activity is not affected by disruption mutations of PMT1-4 |
| 2.4.1.109 | more |
Afpmt1 acts as an O-mannosyltransferase. Characterization of the DELTAAfpmt1 mutant shows that a lack of AfPmt1p results in sensitivity to elevated temperature and defects in growth and cell wall integrity, thereby affecting cell morphology, conidium formation, and germination. In a mouse model, Afpmt1 is not required for the virulence of Aspergillus fumigatus |
| 2.4.1.109 | more |
although the improved secretion of the protein by suppression of O mannosylation might not be a general phenomenon, the suppression of O mannosylation could be beneficial for the production of proteins forming either homomeric or heteromeric complexes through their hydrophobic interaction in yeast |
| 2.4.1.109 | dolichyl phosphate D-mannose + ribonuclease 2 |
biosynthetic pathway |
| 2.4.1.109 | dolichyl phosphate D-mannose + ribonuclease 2 |
C-mannosylation activity |
