EC Number |
Natural Substrates |
---|
2.1.1.361 | 3 S-adenosyl-L-methionine + a [histone H4]-L-lysine20 |
- |
2.1.1.361 | more |
enzyme binding to the nucleosome protects it from degradation during the cell cycle. Full length enzyme has 3.8% of its histone methyltransferase activity on nucleosomes containing the H2A/E61A/ E64A/D90A/E92A mutations compared to wild type nucleosomes |
2.1.1.361 | more |
the enzyme is completely inactive toward histone H4 with a K20L mutation |
2.1.1.361 | more |
the proteolytic degradation of the enzyme is controlled by the SCFSlimb ligase complex |
2.1.1.361 | S-adenosyl-L-methionine + a [histone H4]-L-lysine20 |
- |
2.1.1.361 | S-adenosyl-L-methionine + a [histone H4]-L-lysine20 |
highly specific substrate |
2.1.1.361 | S-adenosyl-L-methionine + a [histone H4]-N6,N6-dimethyl-L-lysine20 |
- |
2.1.1.361 | S-adenosyl-L-methionine + a [histone H4]-N6-methyl-L-lysine20 |
- |
2.1.1.361 | S-adenosyl-L-methionine + [p53]-L-lysine382 |
- |