EC Number   |
Natural Substrates |
|---|
    1.12.98.1 | H2 + coenzyme F420 |
- |
| 1.12.98.1 | H2 + coenzyme F420 |
enzyme of methanogenesis pathway |
| 1.12.98.1 | H2 + coenzyme F420 |
two alternative pathways, the F420-reducing hydrogenase and the Hmd-Mtd cycle (2-dependent methylenetetrahydromethanopterin dehydrogenase (Hmd) and F420H2-dependent methylenetetrahydromethanopterin dehydrogenase (Mtd) together reduce F420 with H2) can function in vivo for the reduction of F420 with H2. Furthermore, during growth on formate the same pathways function in reverse to produce H2 from F420H2. The lack of growth differences between the wild-type and mutant strains on H2 and CO2 suggests that neither pathway for F420 reduction is rate limiting. However, in nature the F420-reducing hydrogenase may constitute the major pathway when sufficient nickel is present, while the Hmd-Mtd cycle may be important when nickel is limiting |
| 1.12.98.1 | H2 + oxidized coenzyme F420 |
- |
| 1.12.98.1 | H2 + oxidized methyl viologen |
- |
| 1.12.98.1 | H2 + thioredoxin |
the frhAGB-encoded hydrogenase can transfer electrons derived from oxidation of H2 to a protein target by direct contact without the involvement of an electron carrier |
| 1.12.98.1 | more |
generation of F420H2 by Fpo with electrons derived from DIET requires an abundance of reduced methanophenazine |
