EC Number   |
Natural Substrates |
|---|
    6.3.4.2 | more |
CTP limitation increases expression of CTP synthase in Lactococcus lactis. At normal CTP concentrations a terminator is preferentially formed in the pyrG leader, thereby reducing expression of CTP synthase. At low CTP concentrations the RNA polymerase pauses at a stretch of C residues inthe pyrG leader, thereby allowing an antiterminator to form and transcription to proceed |
| 6.3.4.2 | more |
in Lactococcus lactis the pyrG gene product is the only enzyme responsible for the amination of UTP to CTP |
| 6.3.4.2 | more |
the enzyme is one of the key enzymes in pyrimidine nucleotide anabolic pathways. The activity of this enzyme is elevated in various malignancies including acute lymphocytic leukemia |
| 6.3.4.2 | more |
CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP |
| 6.3.4.2 | more |
regulation of CTP synthetase activity by CTP plays an important role in the regulation of phospholipid synthesis |
| 6.3.4.2 | more |
the enzyme is allosterically regulated by CTP product inhibition and by reversible phosphorylation |
| 6.3.4.2 | UTP + ATP + NH3 |
the enzyme is regulated in a complex fashion, overview |
