EC Number   |
Natural Substrates |
|---|
   4.1.99.3 | cyclobutadipyrimidine in DNA |
the enzyme converts the energy of light of near UV to visible wavelengths into chemical energy to break the cyclobutane ring of pyrimidine dimers in DNA and thus prevents the lethal and mutagenic effects of far UV, 200-300 nm |
| 4.1.99.3 | more |
enzyme promotes virus survival in the environment |
| 4.1.99.3 | more |
expression in transgenic mice leads to superior survival, reduced acute UV effects like erythema, hyperplasia or apoptosis when treated with photoreactivating light |
| 4.1.99.3 | more |
light-dependent repair of UV-induced damage products in DNA by direct reversal of base damage rather than via excision repair pathways |
| 4.1.99.3 | more |
major pathway to remove UV-induced DNA lesions from the genome |
| 4.1.99.3 | more |
photolyase repairs nucleosome-free DNA rapidly, while repair of nucleosomes is inhibited severely |
| 4.1.99.3 | more |
predominant role of photolyase is CDP repair of an origin or replication |
| 4.1.99.3 | more |
environmental stress enzyme |
| 4.1.99.3 | more |
photoreduction by intraprotein electron transfer is not part of the photolyase photocycle under physiological conditions |
| 4.1.99.3 | more |
absolute dependence of catalysis by photolyase on light |
