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Results 41 - 42 of 42

EC Number	Natural Substrates	Commentary (Nat. Sub.)
3.6.1.23	more	the enzyme has immunomodulatory function in pathogenesis, treatment of human monocyte-derived macrophages with dUTPase from Ebstein-Barr virus induces the expression of proinflammatory cytokines, e.g. interleukin-6, through activation of NF-kappaB via TLR2 receptor, but not TLR3 or TLR4, requiring the adaptor molecule MyD88, but not CD14, overview
3.6.1.23	more	the enzyme limits the activation or degradation of 5-fluorouracil, overview. The expression of dUTPase is significantly different between primary tumours and their corresponding metastatic tumour

Results 41 - 42 of 42

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Release 2023.1 (January 2023)