EC Number   |
Natural Substrates |
|---|
   3.4.24.7 | more |
MMP-1 is a single effector of the Raf/MEK/ERK signaling cascade, that prevents progression of melanoma from a primary to metastatic tumor |
| 3.4.24.7 | more |
MMP1 expression is increased in Xeroderma pigmentosum, a rare, recessively inherited genetic disease characterized by skin cancer proneness and premature aging in photoexposed area |
| 3.4.24.7 | more |
myocardial matrix degradation by MMP-1 induced by thyroid hormone through enzyme activation, enzyme regulation involving suppression of tissue inhibitors of matrix metalloproteinases TIMPs and distribution, overview |
| 3.4.24.7 | more |
substance P up-regulates matrix metalloproteinase-1 and down-regulates collagen in human lung fibroblast, overview |
| 3.4.24.7 | more |
active MMP-10, EC 3.4.24.22, does not cleave collagen type 1 directly, it does activate the collagenase MMP-1 |
| 3.4.24.7 | more |
matrix metalloproteinases are endopeptidases capable of cleaving various components of extracellular matrix |
| 3.4.24.7 | more |
MMP-1 cleaves a specific glycine-isoleucine or glycine-leucine bond in fibrillar collagens, despite the presence of this sequence in other parts of the protein |
| 3.4.24.7 | Type I collagen + H2O |
- |
| 3.4.24.7 | Type I collagen + H2O |
a plasmin/MMP-10/MMP-1 proteolytic axis effectively enhances collagen type 1 degradation |
| 3.4.24.7 | Type I collagen + H2O |
interstitial collagen |
