3.4.24.7	Collagen + H2O	-	
3.4.24.7	collagen I + H2O	degradation	
3.4.24.7	collagen III + H2O	degradation	
3.4.24.7	Collagen type I + H2O	-	
3.4.24.7	Collagen type III + H2O	-	
3.4.24.7	Collagen type III + H2O	ability of MMP-1 to unwind triple-helical collagen	
3.4.24.7	additional information	ligation of keratinocyte alpha2beta1 integrin by type 1 collagen induces expression of matrix metalloproteinase-1. The MMP-1 activity is required for the alpha2beta1 integrin-dependent migration of primary keratinocytes across collagenous matrices. MMP-1 binds to the I domain of the alpha2 intergrin subunit	
3.4.24.7	additional information	matrix metalloproteinase 1 interacts with neuronal integrins and stimulates dephosphorylation of Akt and neuronal death through a non-proteolytic mechanism. MMP-1 might contribute to the neuronal damage which occurs in association with degenerative and inflammatpry conditions characterized by elevated levels of this proteinase	
3.4.24.7	additional information	MMP-1 is involved in intestinal re-epithelization in vivo and is upregulated by cytokines relevant in wound repair	
3.4.24.7	additional information	enzyme regulation on expression and protein levels, overview	
3.4.24.7	additional information	MMP-1 is a single effector of the Raf/MEK/ERK signaling cascade, that prevents progression of melanoma from a primary to metastatic tumor	
3.4.24.7	additional information	MMP1 expression is increased in Xeroderma pigmentosum, a rare, recessively inherited genetic disease characterized by skin cancer proneness and premature aging in photoexposed area	
3.4.24.7	additional information	myocardial matrix degradation by MMP-1 induced by thyroid hormone through enzyme activation, enzyme regulation involving suppression of tissue inhibitors of matrix metalloproteinases TIMPs and distribution, overview	
3.4.24.7	additional information	substance P up-regulates matrix metalloproteinase-1 and down-regulates collagen in human lung fibroblast, overview	
3.4.24.7	additional information	active MMP-10, EC 3.4.24.22, does not cleave collagen type 1 directly, it does activate the collagenase MMP-1	
3.4.24.7	additional information	matrix metalloproteinases are endopeptidases capable of cleaving various components of extracellular matrix	
3.4.24.7	additional information	MMP-1 cleaves a specific glycine-isoleucine or glycine-leucine bond in fibrillar collagens, despite the presence of this sequence in other parts of the protein	
3.4.24.7	Type I collagen + H2O	-	
3.4.24.7	Type I collagen + H2O	a plasmin/MMP-10/MMP-1 proteolytic axis effectively enhances collagen type 1 degradation	
3.4.24.7	Type I collagen + H2O	interstitial collagen	
3.4.24.7	Type I collagen + H2O	production of type I collagen by periodontal ligament cells	
3.4.24.7	type I procollagen + H2O	-	
3.4.24.7	type II collagen + H2O	interstitial collagen	
3.4.24.7	type III collagen + H2O	-	
3.4.24.7	type III collagen + H2O	interstitial collagen