EC Number   |
Natural Substrates |
|---|
   3.4.22.1 | more |
CmCatB2 may be an inactive protease isoform resulting from splicing errors |
| 3.4.22.1 | more |
absence of Ctsb significantly impairs development of high-grade invasive ductal carcinomas and reduces the metastatic burden in the lungs, and cancer cells lacking Ctsb exhibit significantly higher resistance to apoptosis induction by the lysosomotropic agent Leu-Leu-OMe |
| 3.4.22.1 | more |
autocatalytic activation of the inactive proenzyme |
| 3.4.22.1 | more |
cathepsin B belongs to the lysosomal cysteine cathepsins, a third major class of matrix-degrading enzymes involved in tumor invasion and tissue remodeling. Cathepsin B is involved in matrix degradation at podosomes, cysteine protease inhibitors reduce matrix degradation and invasion in vitro |
| 3.4.22.1 | more |
cathepsin B is a lysosomal cysteine protease of the papain-like enzyme family with multiple biological functions |
| 3.4.22.1 | more |
cathepsin B is a target of Hedgehog signaling in pancreatic cancer, downregulation of CATB by Hedgehog, cyclopamine reduces CATB protein and mRNA levels. CATB might influence pancreatic cancer cell invasiveness |
| 3.4.22.1 | more |
cathepsin B is an intracellular lysosomal cysteine proteinase that can degrade extracellular components including collagen and protein turnover in the lysosomal system. Cathepsin B plays an important role in the resolution of organic matrix, a final step in bone resorption. It is also known to play an important role in the initiation and perpetuation of inflammatory processes |
| 3.4.22.1 | more |
cathepsin B is expressed in cerebral aneurysms and promotes the progression of cerebral aneurysms, which include degradation of extracellular matrix in arterial walls in strong subarachnoid hemorrhage, overview |
| 3.4.22.1 | more |
cathepsin B is expressed in induced cerebral aneurysms and promotes the progression of cerebral aneurysms, which include degradation of extracellular matrix in arterial walls in strong subarachnoid hemorrhage, overview |
| 3.4.22.1 | more |
cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages |
