EC Number |
Natural Substrates |
---|
3.4.17.23 | angiotensin II + H2O |
high levels of angiotensin II induces pulmonary arterial hypertension |
3.4.17.23 | QRPRLSHKGPMPF + H2O |
i.e. apein(1-13) |
3.4.17.23 | YGGFLRRIRPKLK + H2O |
i.e. dynorphin A 1-13 |
3.4.17.23 | more |
presence of ACE2 alone is not sufficient for maintaining viral infection. Other virus receptors or coreceptors may be required in different tissues |
3.4.17.23 | more |
the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited |
3.4.17.23 | more |
the enzyme has a function in blood pressure regulation, blood flow and fluid regulation. Loss of ACE2 impairs heart function |
3.4.17.23 | more |
the enzyme is involved in diesease condition including hypertension, diabetes and cardiac function. ACE2 is the SARS virus receptor |
3.4.17.23 | angiotensin II + H2O |
the enzyme is involved in the renin angiotensin system |
3.4.17.23 | angiotensin II + H2O |
the major role of ACE2 in Ang peptides metabolism is the production of Ang-(1-7). ACE2 also participates in the metabolism of other peptides non related to the renin-angiotensin system: apelin-13, neurotensin, kinetensin, dynorphin, [des-Arg9]-bradykinin, and [Lys-des-Arg9]-bradykinin |
3.4.17.23 | angiotensin II + H2O |
the uteroplacental location of angiotensin (1-7) and ACE2 in pregnancy suggests an autocrine function of angiotensin(1-7) in the vasoactive regulation that characterizes placentation and establishes pregnancy |