EC Number   |
Natural Substrates |
|---|
   3.1.4.39 | more |
binding of ATX to activated platelets and lymphocytes in an integrin-dependent manner mediated by the consecutive cysteine-rich somatomedin-B-like, SMB, domains |
| 3.1.4.39 | more |
brain homogenate forms N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso-N-acylphosphatidylethanolamines by a Mg2+-dependent lysophospholipase D, substrate specificity, overview |
| 3.1.4.39 | more |
heterotrimeric G protein subunits Galphaq and Gbeta1 have lysophospholipase D activity, choline production from lysoPAF by the purified FLAG-tagged Galphaq, overview. K52A, T186A, D205A, G48A and Q209L mutant forms of Galphaq show a significant reduction of lysoPLD activity, whereas G48V does not. The decrease of lysoPLD activity of G48A and Q209L is low |
| 3.1.4.39 | more |
zATX preferably hydrolyzes LPC and lysophosphatidylethanolamine but does not efficiently hydrolyze lysophosphatidylserine, lysophosphatidylinositol or sphingosylphosphorylcholine |
| 3.1.4.39 | more |
protein-protein interaction with proteins via the enzyme's SMB1 domain, which binds to the PDE domain. The enzyme binds to activated lymphocytes possibly involving an enzyme lymphocyte- and alpha4beta1-specific 458LDV460 motif. Autotaxin (ATX or ENPP2) is an ectonucleotide pyrophosphatase/phosphodiesterase that functions as a secreted lysophospholipase D to produce the multifunctional lipid mediator lysophosphatidic acid from more complex lysophospholipids |
| 3.1.4.39 | more |
the enzyme converts lysophospholipids such as lysophosphatidylcholine to lysophosphatidic acid |
| 3.1.4.39 | more |
the enzyme hydrolyzes extracellular lysophospholipids into the lipid mediator lysophosphatidic acid, a ligand for specific G protein-coupled receptors |
| 3.1.4.39 | more |
the enzyme is active on human macrophages, erythrocytes, Jurkat and HeLa cells, and on chicken embryo chorioallantoic membrane |
| 3.1.4.39 | sphingosylphosphorylcholine + H2O |
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