3.1.4.39	1-alkyl-sn-glycero-3-phosphocholine + H2O	-	
3.1.4.39	1-alkyl-sn-glycero-3-phosphocholine + H2O	16:0, 18:1 and 18:2-lysophosphatidylcholine are the predominant physiological substrates of the enzyme in rabbit aqueous humor	
3.1.4.39	1-alkyl-sn-glycero-3-phosphoethanolamine + H2O	-	
3.1.4.39	1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine + H2O	may play a role in the metabolism of platelet-activating factor	
3.1.4.39	lysophosphatidyl choline + H2O	-	
3.1.4.39	lysophosphatidylcholine + H2O	-	
3.1.4.39	lysophosphatidylcholine + H2O	present in the plasma	
3.1.4.39	lysophosphatidylcholine + H2O	lysophospholipase D activity	
3.1.4.39	additional information	the product lysophosphatidic acid mediates multiple biological functions	
3.1.4.39	additional information	activity implicated in a large variety of biological processes (during normal development and under pathological conditions). Developmental roles include adipogenesis, intestinal cell motility and neurite morphology, a contribution to disease is described for alzheimer's disease, chronic hepatitis C, multiple sclerosis, neuropathic pain, obesity, rheumatoid arthritis	
3.1.4.39	additional information	binding of ATX to activated platelets and lymphocytes in an integrin-dependent manner mediated by the consecutive cysteine-rich somatomedin-B-like, SMB, domains	
3.1.4.39	additional information	brain homogenate forms N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso-N-acylphosphatidylethanolamines by a Mg2+-dependent lysophospholipase D, substrate specificity, overview	
3.1.4.39	additional information	heterotrimeric G protein subunits Galphaq and Gbeta1 have lysophospholipase D activity, choline production from lysoPAF by the purified FLAG-tagged Galphaq, overview. K52A, T186A, D205A, G48A and Q209L mutant forms of Galphaq show a significant reduction of lysoPLD activity, whereas G48V does not. The decrease of lysoPLD activity of G48A and Q209L is low	
3.1.4.39	additional information	zATX preferably hydrolyzes LPC and lysophosphatidylethanolamine but does not efficiently hydrolyze lysophosphatidylserine, lysophosphatidylinositol or sphingosylphosphorylcholine	
3.1.4.39	additional information	protein-protein interaction with proteins via the enzyme's SMB1 domain, which binds to the PDE domain. The enzyme binds to activated lymphocytes possibly involving an enzyme lymphocyte- and alpha4beta1-specific 458LDV460 motif. Autotaxin (ATX or ENPP2) is an ectonucleotide pyrophosphatase/phosphodiesterase that functions as a secreted lysophospholipase D to produce the multifunctional lipid mediator lysophosphatidic acid from more complex lysophospholipids	
3.1.4.39	additional information	the enzyme converts lysophospholipids such as lysophosphatidylcholine to lysophosphatidic acid	
3.1.4.39	additional information	the enzyme hydrolyzes extracellular lysophospholipids into the lipid mediator lysophosphatidic acid, a ligand for specific G protein-coupled receptors	
3.1.4.39	additional information	the enzyme is active on human macrophages, erythrocytes, Jurkat and HeLa cells, and on chicken embryo chorioallantoic membrane	
3.1.4.39	sphingosylphosphorylcholine + H2O	-