EC Number   |
Natural Substrates |
|---|
    3.1.3.4 | a 3-sn-phosphatidate + H2O |
lipin-1 plays a critical role in the perturbation of hepatic insulin signaling |
| 3.1.3.4 | a 3-sn-phosphatidate + H2O |
lipin-2 is negatively regulated by phosphorylation during mitosis |
| 3.1.3.4 | a 3-sn-phosphatidate + H2O |
phosphatidate phosphatases are key enzymes in lipid biosynthesis and signaling. Type I PAP enzymes participate in de-novo phospholipid biosynthesis, whereas type II PAP enzymes have an established role in lipid signaling. The eukaryotic, endoplasmic reticulum-resident PA-PSP is a bifunctional enzyme with specific type II PAP activity, and regulates, in addition to type I PAPs, the de-novo biosynthesis of phospholipids and triacylglycerols |
| 3.1.3.4 | a 3-sn-phosphatidate + H2O |
the enzyme is involved in lipid synthesis and cell signalling |
| 3.1.3.4 | diacylglycerol diphosphate + H2O |
- |
| 3.1.3.4 | diacylglycerol diphosphate + H2O |
the bifunctional DPP1 catalyzes the removal of the beta-phosphate from diacylglycerol diphosphate to form phosphatidate, reaction of EC 3.1.3.B2, and it then removes the phosphate from phosphatidate to form diacylglycerol, zinc-mediated regulation, overview |
| 3.1.3.4 | lysophosphatidic acid + H2O |
- |
| 3.1.3.4 | lysophosphatidic acid + H2O |
LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids |
| 3.1.3.4 | more |
- |
| 3.1.3.4 | more |
the functional role of the enzyme in lamellar bodies is proposed in relation to glycerophospholipd metabolism |
