EC Number   |
Natural Substrates |
|---|
   2.7.11.10 | ATP + [IkappaB protein] |
- |
| 2.7.11.10 | ATP + [IkappaB protein] |
inhibition and degradation of IkappaB, an inhibitor of NF-kappaB retaining it in the cytoplasm, phosphorylation of IkappaB marks the protein for ubiquitination followed by degradation, activated NF-kappaB is translocated to the nucleus initiating signalling pathways, regulation mechanism, overview |
| 2.7.11.10 | ATP + [IkappaB protein] |
inhibitor substrate is bound to NF-kappaB |
| 2.7.11.10 | ATP + [IkappaB protein] |
parasite IKKalpha, localized in parasitophorous vacuole membrane, activates mouse' intracellular NF-kappaB in early infection stage resulting in NF-kappaB nuclear translocation and subsequent gene expression independently from the host IKK complex |
| 2.7.11.10 | ATP + [IkappaB protein] |
phosphorylation of IkappaB results in its proteolytic degradation |
| 2.7.11.10 | ATP + [IkappaB protein] |
required for activation of NF-kappaB resulting in activation of signalling pathways |
| 2.7.11.10 | ATP + [IkappaB protein] |
signalling step of IKK bound to NFkappaB for subsequent ubiquitination of IkappaB and proteolytic degradation |
| 2.7.11.10 | ATP + [IkappaB protein] |
the IkappaBalpha subunit of NF-kappaB is phosphorylated at serine residues 32 and 36 |
| 2.7.11.10 | ATP + [IkappaBalpha protein] |
- |
| 2.7.11.10 | ATP + [IkappaBalpha protein] |
enzyme is involved in activation of pro-inflammation signalling |
