EC Number |
Natural Substrates |
---|
2.7.11.10 | ATP + IkappaBalpha |
degradation of IkappaBalpha |
2.7.11.10 | ATP + NF-kappaB |
- |
2.7.11.10 | ATP + protein p100 |
interaction with the NF-kappaB complex |
2.7.11.10 | ATP + protein p165 |
p65 is part of the IKKepsilon complex with p25, interaction with the NF-kappaB complex |
2.7.11.10 | ATP + [acetylated histone H3 protein] |
IKKalpha is required for histone function regulation in the nucleus |
2.7.11.10 | ATP + [GST-IkappaB protein] |
- |
2.7.11.10 | ATP + [GST-IkappaBalpha protein] |
- |
2.7.11.10 | ATP + [histone H3 protein] |
- |
2.7.11.10 | ATP + [histone H3 protein] |
histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression |
2.7.11.10 | ATP + [IFN regulatory factor 3 protein] |
IRF3 activation is triggered by IKKepsilon/TBK1-mediated phosphorylation on Ser396 |