EC Number   |
Natural Substrates |
|---|
   2.4.1.109 | more |
protein O-mannosyltransferase isoforms regulate biofilm formation in Candida albicans |
| 2.4.1.109 | more |
Afpmt1 acts as an O-mannosyltransferase. Characterization of the DELTAAfpmt1 mutant shows that a lack of AfPmt1p results in sensitivity to elevated temperature and defects in growth and cell wall integrity, thereby affecting cell morphology, conidium formation, and germination. In a mouse model, Afpmt1 is not required for the virulence of Aspergillus fumigatus |
| 2.4.1.109 | more |
although the improved secretion of the protein by suppression of O mannosylation might not be a general phenomenon, the suppression of O mannosylation could be beneficial for the production of proteins forming either homomeric or heteromeric complexes through their hydrophobic interaction in yeast |
| 2.4.1.109 | more |
disruption of the pmt1 gene decreased protein secretion but has no effect on glycosylation of secreted proteins. PMTI protein O-mannosyltranferase does not take part in glycosylation of these proteins |
| 2.4.1.109 | more |
O-mannosylation of specific secretory proteins of the bacterial pathogen Mycobacterium tuberculosis contributes significantly to virulence |
| 2.4.1.109 | more |
O-mannosylation of specific secretory proteins of the human fungal pathogen Candida albicans contributes significantly to virulence |
| 2.4.1.109 | more |
O-mannosylation of specific secretory proteins of the human fungal pathogen Candida albicans contributes significantly to virulence. PMT2 is essential for growth. Loss of a single PMT2 allele already sufficed to significantly retarded growth |
