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EC Number
Natural Substrates
Commentary (Nat. Sub.)
ATP + (ribonucleotide)n + (ribonucleotide)m
RNA editing, posttranscriptional RNA processing in which uridylate residues are inserted into and deleted from pre-mRNAs to create start and stop codons, also acts to reseal mRNAs cleaved at incorrect sites
ATP + (ribonucleotide)n + (ribonucleotide)m
RNA editing, unique U insertion and U deletion process, involves cycles of pre-mRNA cleavage, terminal U addition or U removal, and religation, band IV is the RNA editing ligase needed to seal in U deletion
ATP + (ribonucleotide)n + (ribonucleotide)m
ATP + (ribonucleotide)n + (ribonucleotide)m
the enzyme is essential for survival of both insect and bloodstream forms of the parasite
the group I intron from cyanobacterium Anabaena sp. catalyzes phosphodiester bond formation using a triphosphate on the 5'-terminal nucleotide, much like protein polymerases and engineered ribozymes. In the process, this ribozyme forms a unique circular RNA that incorporates the exogenous guanosine cofactor added during self-splicing
ATP + (ribonucleotide)n + (ribonucleotide)m
the L1 ligase is regioselective for formation of the biologically relevant 5' to 3' phosphodiester bond rather than a 5' to 2' bond
ATP + (ribonucleotide)n + (ribonucleotide)m
Trl1 executes the end-healing and end-sealing steps of tRNA splicing, requires a 2'-PO4 end for tRNA splicing in vivo
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