EC Number   |
Metals/Ions |
Reference |
|---|
   2.7.11.22 | Ca2+ |
induces cleavage of p35 to p25 by calpains, which changes the localization of Cdk5 from the particluate to the soluble fraction |
666467 |
| 2.7.11.22 | Ca2+ |
induces cleavage of p35 to p25 by calpains, which changes the localization of Cdk5 from the particulate to the soluble fraction |
666467 |
| 2.7.11.22 | Ca2+ |
stimulates Cdk5, Ca2+/calmodulin induce the phosphorylation of p35 by Cdk5 after stimulation of the Ca2+-permeable cation channels NMDA receptor and kainate receptor, leading to cleavage of p35 to p25 |
666117 |
| 2.7.11.22 | Cd2+ |
can partially substitue Mg2+ |
490935 |
| 2.7.11.22 | Co2+ |
can partially substitue Mg2+ |
490935 |
| 2.7.11.22 | Mg2+ |
- |
489976, 490796, 490797, 490800, 490931, 662124, 662152, 662686, 662688, 662855, 662926, 663933, 664005, 664030, 664160, 664179, 665488, 665497, 665645, 665977, 665980, 665982, 666109, 666120, 666401, 666440, 666468, 666588, 666635, 666728, 666744 |
| 2.7.11.22 | Mg2+ |
coordinated by D145 |
666862 |
| 2.7.11.22 | Mg2+ |
dependent on, Mg2+ is the physiologic metal ion, other divalent cations are able to support nucleotide binding, but only Mn2+, Co2+, and Cd2+ can substitute Mg2+ in supporting the catalytic activity |
490935 |
| 2.7.11.22 | Mg2+ |
required |
722123, 722706, 723656, 723745 |
| 2.7.11.22 | Mn2+ |
- |
665968 |
