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Literature summary for 2.7.11.22 extracted from
- The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator (2003), Neurosignals, 12, 221-229.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| p35 | activation subunit, required, interacts with and activates Cdk5, laminin induces upregulation of p35, regulation of p35 expression, overview | Mus musculus | |
| p35 | activation subunit, required, interacts with and activates Cdk5, laminin induces upregulation of p35, regulation of p35 expression, overview | Homo sapiens | |
| p35 | activation subunit, required, interacts with and activates Cdk5, laminin induces upregulation of p35, regulation of p35 expression, overview | Rattus norvegicus | |
| p39 | activation subunit, can substitute for p35, interacts with and activates Cdk5 | Mus musculus | |
| p39 | activation subunit, can substitute for p35, interacts with and activates Cdk5 | Homo sapiens | |
| p39 | activation subunit, can substitute for p35, interacts with and activates Cdk5 | Rattus norvegicus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| regulation of p35 expression, overview | Mus musculus |
| regulation of p35 expression, overview | Homo sapiens |
| regulation of p35 expression, overview | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | glutamate triggers the ubiquitination and subsequent degradation of p35 in neurons after autophosphorylation of Cdk5-p35 at p35 | Homo sapiens | |
| additional information | glutamate triggers the ubiquitination and subsequent degradation of p35 in neurons after autophosphorylation of Cdk5-p35 at p35 | Mus musculus | |
| additional information | glutamate triggers the ubiquitination and subsequent degradation of p35 in neurons after autophosphorylation of Cdk5-p35 at p35 | Rattus norvegicus | |
| roscovitine | - |
Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoskeleton | Cdk5-p35 | Mus musculus | 5856 | - |
| cytoskeleton | Cdk5-p35 | Rattus norvegicus | 5856 | - |
| membrane | Cdk5-p35 | Mus musculus | 16020 | - |
| membrane | Cdk5-p35 | Rattus norvegicus | 16020 | - |
| additional information | Ca2+ induces cleavage of p35 to p25 by calpains, which changes the localization of Cdk5 from the particulate to the soluble fraction | Mus musculus | - |
- |
| additional information | Ca2+ induces cleavage of p35 to p25 by calpains, which changes the localization of Cdk5 from the particulate to the soluble fraction | Rattus norvegicus | - |
- |
| soluble | Cdk5-p25 | Mus musculus | - |
- |
| soluble | Cdk5-p25 | Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | induces cleavage of p35 to p25 by calpains, which changes the localization of Cdk5 from the particluate to the soluble fraction | Mus musculus | |
| Ca2+ | induces cleavage of p35 to p25 by calpains, which changes the localization of Cdk5 from the particulate to the soluble fraction | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + tau protein | Mus musculus | cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35 | ADP + phosphorylated tau protein | - |
? | |
| ATP + tau protein | Rattus norvegicus | cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35 | ADP + phosphorylated tau protein | - |
? | |
| additional information | Homo sapiens | the CDKs are involved in regulation of cell cycle and neuronal differentiation | ? | - |
? | |
| additional information | Mus musculus | the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia | ? | - |
? | |
| additional information | Rattus norvegicus | the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| additional information | p35 and cyclin B are ubiquitinated prior to degradation, proteasomal degradation of p35 is induced by phosphatase inhibitor okadaic acid, proteolytic patterns of p35 amd p39, overview | Mus musculus |
| additional information | p35 and cyclin B are ubiquitinated prior to degradation, proteasomal degradation of p35 is induced by phosphatase inhibitor okadaic acid, proteolytic patterns of p35 amd p39, overview | Homo sapiens |
| additional information | p35 and cyclin B are ubiquitinated prior to degradation, proteasomal degradation of p35 is induced by phosphatase inhibitor okadaic acid, proteolytic patterns of p35 amd p39, overview | Rattus norvegicus |
| phosphoprotein | in S/G2 phase of the cell cycle, Cdk1/Cdc2, upon binding of cyclin B, is phosphorylated and inactivated at T14, Y15, and T161 by protein kinases Wee1 and CAK, to activate the enzyme T14 and Y15 are dephosphorylated by phosphatase Cde25, the active enzyme is only phosphorylated at T161, release of cyclin B results in complete dephosphorylation of Cdk1/Cdc2, overview, Cdk5 binds p35 and is then activated by phosphorylation at T14, Y15, and S519, the bound p35 is also autophosphorylated by Cdk5-p35 at a single site, which induces ubiquitination and subsequent degradation of p35 in neurons, release of p35 leads to dephosphorylation of Cdk5, overview | Homo sapiens |
| phosphoprotein | in S/G2 phase of the cell cycle, Cdk1/Cdc2, upon binding of cyclin B, is phosphorylated and inactivated at T14, Y15, and T161 by protein kinases Wee1 and CAK, to activate the enzyme T14 and Y15 are dephosphorylated by phosphatase Cde25, the active enzyme is only phosphorylated at T161, release of cyclin B results in complete dephosphorylation of Cdk1/Cdc2, overview, Cdk5 binds p35 and is then activated by phosphorylation at T14, Y15, and S519, the bound p35 is also autophosphorylated by Cdk5-p35 at a single site, which induces ubiquitination and subsequent degradation of p35 in neurons, release of p35 leads to dephosphorylation of Cdk5, overview | Rattus norvegicus |
| phosphoprotein | in S/G2 phase of the cell cycle, Cdk1/Cdc2, upon binding of cyclin B, is phosphorylated and inactivated at T14, Y15, and T161 by protein kinases Wee1 and CAK, to activate the enzyme T14 and Y15 are dephosphorylated by phosphatase Cde25, the active enzyme is only phosphorylated at T161, release of cyclin B results in complete dephosphorylation of Cdk1/Cdc2, overview, Cdk5 binds p35 and is then activated by phosphorylation at T14, Y15, and S519, the bound p35 is also autophosphorylated by Cdk5-p35 at a single site, which induces ubiquitination and subsequent degradation of p35 in neurons, release of p35 leads to dephosphorylation of Cdk5, overview, cyclin E is bound to and autophosphorylated by Cdk2 leading to its degradation | Mus musculus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Cdk5 from rat brain | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| cerebral cortex | - |
Rattus norvegicus | - |
| hippocampus | - |
Rattus norvegicus | - |
| muscle | - |
Mus musculus | - |
| muscle | - |
Homo sapiens | - |
| muscle | - |
Rattus norvegicus | - |
| neuron | - |
Mus musculus | - |
| neuron | - |
Homo sapiens | - |
| neuron | - |
Rattus norvegicus | - |
| SH-SY5Y cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + tau protein | cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35 | Mus musculus | ADP + phosphorylated tau protein | - |
? | |
| ATP + tau protein | cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35 | Rattus norvegicus | ADP + phosphorylated tau protein | - |
? | |
| ATP + [tau protein] | Cdk5-p25 or Cdk5-p35, see also EC 2.7.11.26 | Mus musculus | ADP + O-phospho-[tau-protein] | - |
? | |
| ATP + [tau protein] | Cdk5-p25 or Cdk5-p35, see also EC 2.7.11.26, phosphorylation at Ser202 and Thr205 | Rattus norvegicus | ADP + O-phospho-[tau-protein] | - |
? | |
| additional information | the CDKs are involved in regulation of cell cycle and neuronal differentiation | Homo sapiens | ? | - |
? | |
| additional information | the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia | Mus musculus | ? | - |
? | |
| additional information | the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cdc2 | - |
Mus musculus |
| Cdc2 | - |
Homo sapiens |
| Cdc2 | - |
Rattus norvegicus |
| Cdk1 | - |
Mus musculus |
| Cdk1 | - |
Homo sapiens |
| Cdk1 | - |
Rattus norvegicus |
| Cdk5 | - |
Mus musculus |
| Cdk5 | - |
Homo sapiens |
| Cdk5 | - |
Rattus norvegicus |
| cyclin-dependent kinase 5 | - |
Mus musculus |
| cyclin-dependent kinase 5 | - |
Homo sapiens |
| cyclin-dependent kinase 5 | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
| ATP | - |
Rattus norvegicus | |
| cyclin B | interacts with and activates Cdc2/Cdk1 | Mus musculus | |
| cyclin B | interacts with and activates Cdc2/Cdk1 | Homo sapiens | |
| cyclin B | interacts with and activates Cdc2/Cdk1 | Rattus norvegicus | |
| cyclin E | interacts with and activates Cdk2 | Mus musculus |
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