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EC Number	Metals/Ions	Commentary	Reference
1.14.13.39	Ca2+	requirement, brain, not liver or lung	440190
1.14.13.39	Iron	2 mol iron-protoporphyrin IX per mol enzyme dimer, the heme-iron is ferric, EPR-and light absorbance spectroscopy	440192
1.14.13.39	Iron	mouse macrophage enzyme: cytochrome P-450 type hemoprotein	440198
1.14.13.39	Iron	protoporphyrin IX heme	440198, 440222, 440223, 440225, 440238
1.14.13.39	Ca2+	the enzyme bears Ca2+/calmodulin dependent cytochrome P-450 reductase activity which catalyzes cytochrome c reduction	440199
1.14.13.39	Ca2+	slight activation	440201
1.14.13.39	Ca2+	cerebellum enzyme is Ca2+-dependent	440202, 440232
1.14.13.39	Ca2+	constitutive endothelial and inducible membrane bound macrophage enzyme are strictly Ca2+-dependent	440204
1.14.13.39	Ca2+	insoluble enzyme	440204
1.14.13.39	Ca2+	macrophage enzyme	440204

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Release 2023.1 (January 2023)