EC Number   |
Metals/Ions |
Reference |
|---|
    1.13.11.34 | Ca2+ |
required |
439449, 439456, 439458, 439459, 439461, 439466, 742210, 742444 |
| 1.13.11.34 | Ca2+ |
stimulates |
439441, 439442, 439443, 439448, 439453, 439479 |
| 1.13.11.34 | Ca2+ |
stimulation with calcium ionophore |
705037 |
| 1.13.11.34 | Ca2+ |
the enzyme is activated by a Ca2+-mediated translocation to membranes |
658043 |
| 1.13.11.34 | Ca2+ |
upon stimulation with calcium ionophore, GFP-5-lipoxygenase translocates to the nuclear envelope allowing it to interact with 5-lipoxygenase activating protein (FLAP) and leukotriene C4 synthase |
702043 |
| 1.13.11.34 | Ca2+ |
whilst the catalytic domain of wild-type 5-LO is destabilized by calcium, addition of calcium has no influence on the catalytic domain of 5-LODELTA4 |
743614 |
| 1.13.11.34 | Fe |
required for catalysis, oxidizes Fe2+ to Fe3+ |
742078 |
| 1.13.11.34 | Fe |
the iron acts as electron acceptor and donor, during hydrogen abstraction and peroxide formation |
711100 |
| 1.13.11.34 | Fe2+ |
- |
704997 |
| 1.13.11.34 | Fe2+ |
a non-heme iron dioxygenase |
741918 |
