EC Number |
Metals/Ions |
Reference |
---|
1.13.11.34 | Ca2+ |
addition of Ca2+ increases catalytic activity of wild-type nzyme by 50% |
726804 |
1.13.11.34 | Ca2+ |
allosteric modulator involved in membrane binding by the enzyme |
741961 |
1.13.11.34 | Ca2+ |
binds at the C2-like domain, stimulates and induces enzyme translocation from the nuclear soluble to the envelope fraction, both Ca2+ and glyceride might decrease the concentration of lipid hydroperoxide needed for activation of 5-LO, enabling cellular 5-LO product formation at a low redox tone |
690170 |
1.13.11.34 | Ca2+ |
Ca2+ is required for 5LO activity, the enzyme contains two Ca2+, full activation is reached at 0.004-0.01 mM Ca2+ |
711100 |
1.13.11.34 | Ca2+ |
Ca2+ stimulates enzyme activity |
712666 |
1.13.11.34 | Ca2+ |
half-maximal activation around 0.03 mM |
439457 |
1.13.11.34 | Ca2+ |
half-maximal activity at 0.02 mM |
439466 |
1.13.11.34 | Ca2+ |
half-maximal activity at 0.1 mM |
439461 |
1.13.11.34 | Ca2+ |
optimal concentration is 2 mM |
439451 |
1.13.11.34 | Ca2+ |
phosphocholine in combination with Ca2+ markedly stimulate the formation of leukotrienes by wild-type 5-LO and C159S/C300S/C416S/C418S mutant, whereas their effect on the 5-LO 3W mutant is small |
741975 |