EC Number   |
Localization |
GeneOntology No. |
Reference |
|---|
   3.4.22.56 | cytoplasm |
- |
GO:0005737 AmiGO QuickGO |
698197, 698767, 701188, 710058 |
| 3.4.22.56 | cytoplasm |
pro-enzyme |
GO:0005737 AmiGO QuickGO |
717462 |
| 3.4.22.56 | cytosol |
- |
GO:0005829 AmiGO QuickGO |
647420, 647613, 647629, 699937 |
| 3.4.22.56 | cytosol |
the N-termini of activated heavy-membrane-bound and cytoplasmic caspase-3 are slightly different: the heavy membrane caspase-3 begins at Lys14, whereas the cytoplasmic enzyme begins at Ser10 |
GO:0005829 AmiGO QuickGO |
647614 |
| 3.4.22.56 | membrane |
bound to heavy membrane fraction, the N-termini of activated heavy-membrane-bound and cytoplasmic caspase-3 are slightly different: the heavy membrane caspase-3 begins at Lys14, whereas the cytoplasmic enzyme begins at Ser10 |
GO:0016020 AmiGO QuickGO |
647614 |
| 3.4.22.56 | mitochondrion |
- |
GO:0005739 AmiGO QuickGO |
647420, 700685, 717470, 718432 |
| 3.4.22.56 | more |
caspase-3 and its activation is not associated with TNF receptosomes. Neither caspase-3 nor cleaved caspase-3 are present in receptosomes |
- |
717539 |
| 3.4.22.56 | more |
co-localization with Fas death domain, FADD |
- |
701153 |
| 3.4.22.56 | more |
p3-mediated cleavage activity abrogates the functions of other crm-1-dependent nuclear export signals with low nuclear export signal activity |
- |
717462 |
| 3.4.22.56 | nucleus |
activated enzyme, the enzyme harbors one crm-1-independent nuclear export signal but no nuclear localization signal residing at the small subunit of caspase-3. The nuclear entry of active caspase-3 is not mediated by passive diffusion, but by its p3-recognition-based specific cleavage activity. The p3-mediated cleavage activity abrogates the function of the nuclear localization signal in caspase-3, which is essential for the active caspase-3 to enter into the nucleus |
GO:0005634 AmiGO QuickGO |
717462 |
