Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Asp-Glu-Val-Asp-aldehyde | IC50 for membrane enzyme: 1 nM | Homo sapiens | |
Asp-Phe-Leu-Asp-aldehyde | IC50 for membrane enzyme: 4.7 nM | Homo sapiens | |
baculovirus p35 | IC50 for membrane enzyme: 0.074 nM | Homo sapiens | |
Val-Glu-Ile-Asp-aldehyde | IC50 for membrane enzyme: 34 nM | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | the N-termini of activated heavy-membrane-bound and cytoplasmic caspase-3 are slightly different: the heavy membrane caspase-3 begins at Lys14, whereas the cytoplasmic enzyme begins at Ser10 | Homo sapiens | 5829 | - |
membrane | bound to heavy membrane fraction, the N-termini of activated heavy-membrane-bound and cytoplasmic caspase-3 are slightly different: the heavy membrane caspase-3 begins at Lys14, whereas the cytoplasmic enzyme begins at Ser10 | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | different processsing of membrane-bound and cytoplasmic enzyme | Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DEVD-4-nitroanilide + H2O | - |
Homo sapiens | DEVD + 4-nitroaniline | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000001 | - |
IC50 for membrane enzyme: 1 nM | Homo sapiens | Asp-Glu-Val-Asp-aldehyde | |
0.0000047 | - |
IC50 for membrane enzyme: 4.7 nM | Homo sapiens | Asp-Phe-Leu-Asp-aldehyde | |
0.000034 | - |
IC50 for membrane enzyme: 34 nM | Homo sapiens | Val-Glu-Ile-Asp-aldehyde | |
0.000074 | - |
IC50 for membrane enzyme: 0.074 nM | Homo sapiens | baculovirus p35 |