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Literature summary for 3.4.22.56 extracted from

  • Krebs, J.F.; Srinivasan, A.; Wong, A.M.; Tomaselli, K.J.; Fritz, L.C.; Wu, J.C.
    Heavy membrane-associated caspase 3: identification, isolation, and characterization (2000), Biochemistry, 39, 16056-16063.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Asp-Glu-Val-Asp-aldehyde IC50 for membrane enzyme: 1 nM Homo sapiens
Asp-Phe-Leu-Asp-aldehyde IC50 for membrane enzyme: 4.7 nM Homo sapiens
baculovirus p35 IC50 for membrane enzyme: 0.074 nM Homo sapiens
Val-Glu-Ile-Asp-aldehyde IC50 for membrane enzyme: 34 nM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol the N-termini of activated heavy-membrane-bound and cytoplasmic caspase-3 are slightly different: the heavy membrane caspase-3 begins at Lys14, whereas the cytoplasmic enzyme begins at Ser10 Homo sapiens 5829
-
membrane bound to heavy membrane fraction, the N-termini of activated heavy-membrane-bound and cytoplasmic caspase-3 are slightly different: the heavy membrane caspase-3 begins at Lys14, whereas the cytoplasmic enzyme begins at Ser10 Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification different processsing of membrane-bound and cytoplasmic enzyme Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DEVD-4-nitroanilide + H2O
-
Homo sapiens DEVD + 4-nitroaniline
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000001
-
IC50 for membrane enzyme: 1 nM Homo sapiens Asp-Glu-Val-Asp-aldehyde
0.0000047
-
IC50 for membrane enzyme: 4.7 nM Homo sapiens Asp-Phe-Leu-Asp-aldehyde
0.000034
-
IC50 for membrane enzyme: 34 nM Homo sapiens Val-Glu-Ile-Asp-aldehyde
0.000074
-
IC50 for membrane enzyme: 0.074 nM Homo sapiens baculovirus p35